DOWN-REGULATION OF EVI1 IS ASSOCIATED WITH EPIGENETIC ALTERATIONS AND GOOD PROGNOSIS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA

Down-regulation of EVI1 is associated with epigenetic alterations and good prognosis in patients with acute myeloid leukemia

Background The EVI1 gene (3q26) codes for a zinc finger transcription factor with important roles in both mammalian development and leukemogenesis.Over-expression of EVI1 through either 3q26 rearrangements, MLL fusions, or other unknown mechanisms confers a poor prognosis in acute myeloid leukemia.Design and Methods We analyzed the prevalence and p

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Clinico-Epidemiological Profile and Treatment Pattern of Vitiligo in Selected Dermatological Clinics of Mekelle City, Northern Ethiopia

Background.Vitiligo is not a well-studied disease in Ethiopia.Therefore, flex 4 heartworm test this study assessed its clinico-epidemiological profile and treatment patterns.Methods.An institutional-based cross-sectional study was conducted in conveniently selected dermatologic clinics of Mekelle city, Ethiopia.A two-phased study was conducted, in

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